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4.2 Marine derived compound Natural marine-derived chemicals might have several pharmacologic effects and could be extremely beneficial for the creation of novel medicines ( 4.2.1 Archaea Many superheats may produce Zwitterionic organic products to avoid thermal denaturation and protein aggregation under severe circumstances like as extreme temps and osmolarity ( 4.2.2 Bacteria Ancillary marine compounds provide a rich pharmacological source with new chemical structures and a wide range of biological activity (Nikapitiya, 2012