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Introduction Vitamin C, also known as ascorbic acid (the anti-scurvy vitamin), is an essential human body nutrient, first identified in the 1920s by Albert von Szent Gyrgyi [1]

J Exp Med 218:e20190086 Fontana L, Partridge L, Longo VD (2010) Extending healthy life spanfrom yeast to humans

It is the most powerful biological antioxidant in the human body, but premature infants have a deficiency of reduced glutathione, which increases with an increase in the degree of prematurity

Inhibiting mTOR signaling in CAR T cells alters immunometabolism and enhances function Intrigued by our pre- and post-infusion results suggesting a significant role for mTOR activity on the efficacy of CAR T cells of LTR, we asked whether we could harness the mTOR pathway to enhance antitumor activity of CAR T cells of STR