Abbreviations AE: Adverse event AUC 0t : Area under the plasma concentration-time curve from time zero to time AUC 0 : Area under the curve from time 0 extrapolated to infinity AUC _%Extrap : Greater than 20% extrapolation BMI: Body mass index CI: Confidence interval C max : Peak plasma concentration ECG: Electrocardiogram HPLC-MS/MS: High-performance liquid chromatographytandem mass spectrometry PK: Pharmacokinetic SAE: Serious adverse event T max : Time to reach the peak plasma concentration t 1/2 : Elimination half-life z : Elimination rate constant References Gao Q, Zhen K, Xia L, et al
2.8 Permeability to lactulose The protocol for measuring monolayer permeability to lactulose was adapted from (37)
BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions
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28-day, ICU and in-hospital mortality The odds of 28-day mortality and in-hospital mortality was reduced in PCT guidance compared to SOC, the former being statistically significant (OR 0.84, 95% CI: 0.74, 0.95, p = 0.008 (Additional file 1: Figure S2) and OR 0.85, 95% CI: 0.66, 1.10 (Additional file 1: Figure S3), respectively)