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Steiropoulos P, Papanas N, Nena E, et al

Amelioration of hepatic metabolic disease by thyroid hormones in preclinical and clinical studies has spurred the development of thyromimetics that target THRB (the predominant thyroid hormone receptor isoform in the liver) and/or the liver itself to provide more selective activation of hepatic thyroid hormone-regulated metabolic pathways while reducing thyrotoxic side effects in tissues that predominantly express THRA such as the heart and bone

Science 359:11511156 Zhu Y et al (2014) Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

Typical dosage ranges include: General health and energy support: 500 mg 2,000 mg per day Exercise performance or fat metabolism: 1,000 mg 3,000 mg per day Metabolic support: often within the 13 gram daily range For most active individuals, 12 grams daily is a common starting point

Gaspar ML, Meo T, Tosi M