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In smoke-induced pulmonary fibrosis models, tranilast treatment significantly reduced inflammatory cytokines (IL-1, TNF-, TGF-1), oxidative stress, and NF-B expression, while also inhibiting fibroblast proliferation in lung tissue [150]

Various mechanisms may underlie the inhibitory effect of melatonin on tau hyperphosphorylation, as depicted in Fig

Its involvement in tissue development, particularly in the retina and brain, has been extensively documented (Jabari et al., 2022

doi: 10.1016/s0899-9007(00)00354-3 268 RenaudeauD.CollinA.YahavS.De BasilioV.GourdineJ