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1 Introduction Psoriasis, a chronic inflammatory skin disease, affects an estimated 125 million individuals globally, with prevalence rates varying among ethnic groups, typically ranging from 0.33% to 0.6% ( Thymoquinone (TQ), a bioactive compound of Nigella sativa seeds, has emerged as a therapeutic candidate for various diseases due to its diverse pharmacological properties ( Therefore, in light of the limitations associated with current psoriasis therapies and the promising preclinical data on TQs anti-psoriatic effects, this review comprehensively evaluates the existing scientific knowledge regarding the therapeutic potential of TQ for psoriasis

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