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The sulfation pathway, driven by SULT enzymes, is a major secondary mechanism for clearing histamine and other phenolic compounds from the gut and liver

In guinea pig spinal cord homogenate-induced experimental autoimmune encephalomyelitis (EAE) in rats, chronic caffeine reduces disease incidence, attenuates clinical severity, and decreases inflammatory infiltration and demyelination during both peak and recovery phases [59]

This makes it a promising ingredient for slimming and anti-cellulite products

von Montfort, C., Beier, J

As expected for enzymes that share the same co-substrate, some of the residues contributing to the recognition of GSH, Ser92 and Asp172, are conserved