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Owing to its high energy demand, the heart is particularly susceptible to disruptions in mitochondrial biosynthesis, dynamics, and autophagy

Persistent accumulation of activated myofibroblasts within lesional tissue, the hallmark of SSc and other forms of fibrosis, is induced by transforming growth factor- (TGF-), interleukin-6 (IL-6), and a host of other soluble factors 3,8

Continued resistance training, adequate protein intake, regular physical activity, and mindful eating are the actual determinants of long-term success

The addition of lipoic acid further increased improvements in both clinical symptoms and NCV