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The inhibition (%) was calculated as 100- ((fluorescence compound fluorescence negative control )/(fluorescence positive control fluorescence negative control )) 100, where wells with GSDME activation without compounds were used as positive control and wells with liposome alone as negative control, inhibition of 70% was chosen as a threshold

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In addition, uncarboxylated osteocalcin was reported to be positively correlated with CKD progression and proteinuria although OC levels did not consistently reflect vitamin K status, and Gas6 levels were elevated in CKD and inversely correlated with eGFR showing potential involvement in CKD progression (66)

The above information clearly suggests that antioxidants play a crucial role in maintaining homeostasis and in amelioration of the harmful effect of oxidative stress

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