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France 31 , 987-91 , 1904) is a tripeptide (gamma-glutamyl-cysteinyl-glycine, often indicated as GSH) normally present in animal cells and involved as enzymatic substrate in numerous biochemical processes, mainly with the role of detoxifying agent (elimination of toxins in the form of a glutathionyl-derivative), metal chelating agent and reducing agent

Oxidative stress may also down-regulate other essential enzyme systems associated with the methionine cycle, including methionine synthase, betaine-homocysteine methyltransferase and methionine adenosyltransferase, leading to further monoamine neurotransmitter disruption and weakening of antioxidant enzyme activities (Guildford)

Lymphocyte proliferation and immune responses require vast metabolic resources, especially thiols such as cysteine and glutathione

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Following this regimen, a comprehensive evaluation of hepatic, renal, and myocardial toxicity was conducted