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NAD+ addresses mitochondrial function in remaining muscle mass

A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer

Importantly, it should be highlighted that when CD38 is catalyzing the degradation of NAD to ADPR, or the cyclization of NAD to cADPR, there is NAD consumption and nicotinamide generation, leading to the crucial role of CD38 in tissue NAD and nicotinamide homeostasis [6, 34-35, 38-40]