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Hypoglycaemia: As noted above, the risk with incretin monotherapy is generally low in healthy individuals but is heightened by concurrent use of insulin or sulphonylureas, extreme caloric restriction, or prolonged strenuous exercise

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As no relevant changes in e-GST levels were observed for bovine species (see Results section), all other mammalian species were tested without considering these physiological phases

Another concern of BP-3 is that it shows some estrogenic activity , though it's probably not relevant when applied topically to the skin

[PubMed] [Google Scholar] 23.Jalilpiran Y, Hajishafiee M, Khorshidi M, Rezvani H, Mohammadi-Sartang M, Rahmani J, et al