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The presence of a twisted spermatic cord, often seen as the whirlpool sign (characterized by a sudden change in the course of the spermatic cord, forming a spiral twist at the level of the external inguinal ring or within the scrotal sac), and/or absent blood flow within the affected testicle confirms TT and necessitates immediate surgical exploration [354, 359,360,361]

50-residue insertion (that is, E151P197), appearing as the head and being located in the periplasmic region

This article comprehensively reviews 12 different mechanisms of cell death related to the pathogenesis of CD: apoptosis, necroptosis, pyroptosis, parthanatos, ferroptosis, autophagy-dependent cell death, cuproptosis, oxeiptosis, entotic cell death, netotic cell death, lysosome-dependent cell death, and alkaliptosis

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Tashkin DP, Celli B, Senn S, et al