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In immunologically'cold'pancreatic and glioma tumor models, the combination of ZnCDA with RT resulted in a marked amplification of the anti-tumor effects

Prior studies in rats demonstrated that Polysaccharide Iron Complex (PIC), administered as a single oral dose to Sprague Dawley rats did not produce evidence of toxicity at a dosage level of 5000 mg Iron/kg: (An Acute Oral Toxicity Study in Rats with Polysaccharide-Iron Complex

Lee WY, Park JS, Noh SY, Rhee EJ, Kim SW, Zimmet PZ

Acta Neurol.Taiwan

In addition, in this case, the patient exhibited accelerated red blood cell destruction, rapid progressive decline in hemoglobin, significant elevation of indirect bilirubin and lactate dehydrogenase