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J Am Med Womens Assoc (1972)

In the loading dose group, daily intranasal cobalamin administration led to a rapid rise in total serum vitamin B12 levels, increasing from a median of 230 to 1090 pmol/L within two weeks

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Because of these risks, informed consent is critical

In this Review, we discuss current understanding of the functions of NAMPT and highlight progress made in identifying the physiological role of NAMPT and its relevance in various human diseases and conditions, such as obesity, NAFLD, T2DM, cancer and ageing