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This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models

Oral administration significantly reduces lipogenic activity and increases lipolytic activity in adipose tissue, with concurrent increases in fat and glucose oxidation and elevated energy expenditure

doi:10.1007/s00394-014-0706-z [2] Cui X, Mi T, Xiao X, et al

Experimental vascular studies using isolated rat aorta preparations reported that BPC-157 modulated vasomotor tone and increased nitric oxide generation through activation of the SrcCaveolin-1endothelial nitric oxide synthase (eNOS) signaling pathway [3]

(PubMed) Winther KH, Watt T, Bjorner JB, et al