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In the cochlea, it has been hypothesized that cochlear mitochondrial redox imbalance and mtDNA mutations and deletions may be synergistically involved in ARHL ( Mitophagy maintain mitochondrial homeostasis Mitochondria in cells with high energy demand are often numerous, forming an expansive dynamic functional and structural network that requires certain mechanisms to maintain the homeostasis of the mitochondrial network

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PER2 and CRY1, have been reported to suppress the activity of VEGF promoter induced by hypoxia in the luciferase reporter gene analysis, thereby contributing to the circadian fluctuations of VEGF mRNA expression 39

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