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We advocate conducting prospective clinical studies to validate proposed biomarkers, to provide improved mechanistic understanding of the interactions among oxidative stress, genomic stability, and metabolic regulation in oocyte aging, and to allow a rigorous evaluation of antioxidant and environmental interventions with clear clinical endpoints

doi: 10.1074/jbc.M109.077271

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Unfortunately, the small sample size and the lack of thyroid function data of enrolled patients prevent drawing conclusions on this possible effect

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