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Tissue injury disorders present grievous clinical problems and are likely to increase since they are generally associated with the prevailing diseases such as diabetes, hypertension and obesity

M3 receptors are primarily responsible for the normal contraction of the urinary bladder, although M2 receptors are also present, and my act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Andersson & Arner, 2004)

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