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Interestingly, prostaglandin E2 has been implicated in inflammation and pain, Blau said

Symptoms of shingles rash include fever, headache, chills, and an upset stomach

Subsequent investigations in RGS7 / mice reveal that the absence of RGS7 leads to a deceleration in the deactivation kinetics of GABA-activated GIRK channels in hippocampal neurons (Ostrovskaya et al., 2014)