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Clinical data suggests variation in individual tolerance levels, with factors like genetic polymorphisms and pre-existing conditions affecting susceptibility to adverse effects

Stephan 2005

4.1.6 CUL4A-DDB1-CDT2 The CUL4A-DDB1-CDT2 E3 ubiquitin ligase complex is an important regulator of the mammalian circadian clock, acting through both protein turnover and chromatin modifications