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Another significant prospective study evaluated 25 patients with oily skin that received intradermal forehead injections of botulinum toxin and revealed significantly lower sebum production per a sebumeter at one week and one, two, and three months after the injections.[62] Additionally, 91 percent of subjects were satisfied with intradermal botulinum toxin as a treatment for their oily skin.[62] In terms of the mechanism of action, botulinum toxin cleaves proteins involved in vesicle fusion with the plasma membrane of the presynaptic neurons axon terminal