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In response to extracellular ATP, the P2X 7 purinergic receptors may shift from rapid-gating channels selective for small cations to more slowly developing dilated pore conformations permeable to molecules up to 900 Da (North, 2002) and thus facilitate glutamate release under pathological conditions (Duan et al., 2008

Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

Lipid metabolism, which has become a puzzle, can be elucidated with many randomized controlled trials, and lipid guidelines can be reorganized

Zhang Y, Su SA, Li W, Ma Y, Shen J, Wang Y et al (2021) Piezo1-mediated mechanotransduction promotes cardiac hypertrophy by impairing calcium homeostasis to activate calpain/calcineurin signaling

It is the precursor of LTA4 (leukotriene A4, a reactive epoxide), which is glutathionylated by LTC4 synthase (a microsomal glutathione S-transferase) to LTC4 (a pro-inflammatory lipid)