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The FDA, the European Medicines Agency (EMA) and national bodies such as the UK's MHRA and Australia's TGA have each forced withdrawals in this class

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(99m)Tc-CD3813: a nanobody-based single photon emission computed tomography radiotracer with clinical potential for myeloma imaging and evaluation of CD38 expression

It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Sanjay et al., 2022

Minimal systemic effects: Does not significantly alter glucose levels or IGF-1 activity