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Circulation Research 2026 PMID: 42233213, DOI: 10.1161/circresaha.126.326822

This fragmentation and membrane modification process did not impair the biological effects of SP (Supplementary Figs

It can also be taken as a supplement as a liposomal formulation or in the form of S-acetyl-glutathione, although these also appear to have limited impact on raising glutathione levels in the body

In conclusion, we suggest that APR-246 exerts its cytotoxic effect through various cell death pathways

DRUG INDUCED ACCUMULATION OF mtDNA DAMAGE Because mitochondria contain their own DNA, mitochondrial genome integrity is essential for organelle function