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CONCLUSION Given the suboptimal treatment outcomes frequently observed in PHN patients with nerve damage, we propose a novel therapeutic approach that targets both the structural damage and functional dysregulation characteristic of PHN

For the heart rate, at time points 0 and 10 min after administration there were no significant differences between the groups, while later on there were significant differences between Mel and Dex groups: patients receiving Dex by any route of administration had lower heart frequencies (after 10 and 60 min, p = 0.003

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Aortic rings were then pre-contracted with 3 M PE