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The high reactivity of HNE results from the diminished electron density around carbon-3 of HNE as a consequence of two factors: 1 ) the resonance between the C=C of carbons-2 and -3 and the C=O bond of the aldehyde functional group on carbon-1 and 2 ) the inductive effect of the more electronegative O atom on the OH group of carbon-4 with the electrons around carbon-3

About this article Cite this article Lu, C., Zhang, P., Li, S

10.1021/jm100022r J Med Chem

Paschalis A, Sheehan B, Riisnaes R, Rodrigues DN, Gurel B, Bertan C, et al

But the gap between good results and exceptional results often comes down to precision in these three variables