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Dysbiosis of the gut microbiota is accompanied by an increased production of trimethylamine-N-oxide (TMAO), which interferes with the binding of bile acids to FXR and promotes fat synthesis, exacerbating obesity (Tan et al., 2019

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CI activity, in particular, requires adequate levels of reduced GSH in the mitochondria for its function 120,121

[DOI] [PubMed] [Google Scholar] 62.Madanchi M., Fagagnini S., Fournier N., Biedermann L., Zeitz J., Battegay E., Zimmerli L., Vavricka S.R., Rogler G., Scharl M