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The main pathways studied include the mitogen-activated protein kinase (MAPK) pathways and phosphoinositide-3-kinase-protein kinase B/protein kinase B (PI3K/Akt), which are activated by several ubiquitous growth factors, such as the insulin-like growth factor-1 (IGF-1) and fibroblast growth factor (FGF), among others, and neuro-specific factors, such as the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) [12,13]

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the metabolic features of distinct regions are likely indicative of tumor aggressiveness and treatment susceptibility ( 2 Core pathways and molecular basis of metabolic reprogramming 2.1 VHLHIF axis-driven glucose/carbon metabolism pathway reprogramming VHL gene mutation or inactivation is one of the most common molecular characteristics of ccRCC

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