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Duloxetine (Cymbalta ), a serotonin and norepinephrine reuptake inhibitor (SNRI), is used in preclinical antidepressant studies for treatment-resistant depression

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In addition to the docking score and the RMSD of GSSG, we also considered the S-S distance between GSSG and each cysteine residue in GLRX, as a short distance is required for the consequent glutathionylation process