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Non-synonymous single nucleotide mutations in P53 codon 47, S47, do not affect most P53 functions, but their tumor suppressive effects are impaired, and S47 heterozygous and pure mice are significantly more susceptible to the liver and other cancers, which may be related to impaired negative regulation of SLC7A11 by S47, consequently inhibiting ferroptosis [115,116,117,118,119]

Nadiah H, Hannah M, Lee K, Mohd Jofrry S, Long C

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This property along with tissue/tumor expression of GT was used to develop -glutamyl prodrugs

It is primarily synthesized in the liver by the transsulfuration pathway and exported to provide precursors for in situ GSH synthesis by other tissues