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Journal of Cellular and Molecular Medicine, 15, 1703-1712

Immunomodulatory Role of Urolithin A on Metabolic Diseases

In addition, other studies on 24 months rats revealed marked 40 % decrease of PDHC activity, with concomitant increases in expression and activity of pyruvate dehydrogenase kinase (ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase, EC 2.7.11.2.), yielding hiperphosphorylation of PDHC-E1 subunit