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Pulak Ranjan Nath, Lentigen Technology Inc., A Miltenyi Biotec Company, Gaithersburg, MD, United States This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Understanding this dual mechanism underscores the need for dose optimization and precise pharmacokinetic profiling to enhance metformins therapeutic potential while minimizing adverse effects in cardiovascular disease management

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