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Cu/Zn-SOD is mostly found in the cytosol, mitochondria and chloroplasts, while Mn-SOD is primarily found in the peroxisomes and mitochondria

A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

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