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Saudi Sidr honey was demonstrated to arrest the G0/G1 phase in colorectal (HCT-116), breast (MCF-7) and lung (A-549) cancer cells, shortening the S, G2, and M phases ( 4.3 Anti-inflammatory mechanisms Chronic inflammation is an established driver of tumorigenesis, promoting malignant transformation, angiogenesis, immune evasion, and extracellular matrix remodeling ( Honeys polyphenolic constituents, in particular caffeic acid phenethyl ester (CAPE), gallic acid, and chrysin, exert potent anti-inflammatory effects, targeting these molecular pathways ( Table 3 )

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In terms of specific immune-related adverse events, the incidence of diarrhea/colitis and pneumonitis was not associated with a particular checkpoint inhibitor class in contrast to data in the literature