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305 Targets should also be quantifiable by readily available indicators 306 that may miss the complexity of a disease but are straightforward to collect by all countries, regardless of capacity (appendix p

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Lactylation drives macrophage polarization toward the M2 phenotype and upregulates key regulators such as METTL3 in myeloid cells, thereby sustaining the activation of immunosuppressive signaling pathways including JAK-STAT (75, 80)

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The same phenomenon has been observed in ARF19 and ELF3 condensates, both of which sequester TFs from accessing transcriptional targets 24,99