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Upon preincubation of the cancer cells with the antioxidant NAC and subsequent treatment with NP4, the GSH/GSSG ratio was significantly less influenced, reaching a GSH/GSSG ratio of 0.71 (Fig

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214 This process is performed in repeated cycles, each of which removes a two-carbon acetyl-coA from the acyl-CoA via four enzymes, the enoyl-CoA hydratase, ketoacyl-CoA thiolase, acyl-CoA dehydrogenase (ACADs) and hydroxyacyl-CoA dehydrogenase (HADH)

doi: 10.3390/cancers14153604 121 OgiwaraTNagmAYamamotoYHasegawaTNishikawaAHongoK

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