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We therefore turned to ATPase assays under various conditions, as many ABC transporters have been reported to couple ATP hydrolysis to substrate transport (Fig

Additionally, the endogenous administration of BDNF was shown to protect neurons within the substantia nigra from 6-OHDA and MPTP toxicity, both in rat and primate Parkinson models [31]

A deep understanding of the pathogenic mechanisms of PD is of crucial importance for overcoming the limitations of current single-target therapies and for developing synergistic treatment strategies capable of simultaneously intervening at multiple key nodes (Fig

doi: 10.1016/j.gene.2018.07.035

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