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In an autocrine mechanism, SASP factors reinforce the cellular senescence of the senescent cells themselves, while in a paracrine mechanism, they are responsible for inducing senescence in surrounding cells [35]

A: Frequency varies based on individual needs, typically ranging from weekly to monthly after initial loading doses

Furthermore, end-of-life pathology confirmed that deaths due to cancer were significantly reduced, while those attributable to unknown causes were increased by mAb treatment (Table 1

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