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The receptors of vitamin D ( VDR ) are cytosolic, and once the D-VDR complex is formed, it moves into the nucleus, where it associates with the RXR factor, thereby mediating gene transcription [134]

limited evidence

Accessed 6/23/2021, Hirsch AG, Poulsen MN, Nordberg C, et al

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In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity