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Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

One curious characteristic of the Spitz tumor pathway is inactivation of CDKN2A (often the only genetic alteration), with loss of p16 expression, which would be of concern in melanocytic tumors in any other pathway.47 Therefore, malignant transformation requires other mutations in addition to inactivation of CDKN2A, for example, TERT promoter mutations

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Conversely, subcortical -tocopherol levels (63.6 pmol/mg) were slightly higher than cortical levels (57.1 pmol/mg), raising the possibility that different vitamin E isomers serve distinct neuroprotective functions depending on brain region [1]

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