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Additionally, 80% of patients had defects in respiratory chain enzyme complexes, with 35% displaying isolated complex I defects (33)

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5.2 Autism spectrum disorder ASD mostly occurs in infants and young children after the age of 2 years, and is mostly manifested as social communication deficits and the existence of limited, repetitive behaviors or interests, which are improved by the commonly used drugs risperidone and aripiprazole, while ASD patients have a higher probability of suffering from depression, anxiety, sleep difficulties, epilepsy, and intellectual disability (131)