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Compared to younger individuals, this vitamin deficiency is more common in older adults because of the higher prevalence of food-bound vitamin B 12 malabsorption (atrophic gastritis) and the higher incidence of the autoimmune condition, pernicious anemia (39)

reported increasing levels of 8-OH-dG in leukocyte DNA from healthy controls to undialyzed CKD patients, with the highest levels found in HD patients [51]