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Collinson et al

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex

4187-A CLAUDIN-1 MEDIATES CHOLANGIOCELLULAR CARCINOMA INVASION AND METASTASIS BY REPROGRAMMING THE TUMOR MICROENVIRONMENT Zeina Nehme 1 , Marion Muller 1,2 , Emilie Crouchet 1 , Frank Juehling 1 , Julien Moehlin 1 , Natascha Roehlen 1 , Patrick Pessaux 1,3 , Emanuele Felli 1,3 , Lipika Goyal 4 , Roberto Iacone 5 , Alberto Toso 5 , Luigi Manenti 5 , Ana Venkatasamy 6 , Mirian Fernndez Vaquero 7 , Mathias Heikenwlder 7,8 , Patrice Laquerriere 2 , Nabeel M