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Intra-Brain Distribution After crossing the BBB via specific transporter, a drug, prodrug or nanocarrier can distribute from the brain ISF into the brain parenchymal cells via the same transporter expressed at the cellular membrane followed by the release of parent drug (in case of prodrugs and nanocarriers) or binding to the cell constituents, e.g

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We compared the M 6+ abundance for u SOD1 and gs SOD1 under low (10 V) versus high (70 V) energy CID conditions: at 10 V, gs SOD1 A4V , gs SOD1 G93A and gs SOD1 G37R had a greater proportion of M 6+ than u SOD1 indicating that less energy is required to remove gs SOD1 monomer from the dimer than u SOD1