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While home remedies like lemon and honey, aloe vera, and beetroot can provide gradual change, professional treatments such as laser therapy, chemical peels, and medical-grade lip balms offer faster and more effective results

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Future research should concentrate on (1) elucidating nAChR roles in genetic PD subtypes (e.g., GBA or SNCA mutation carriers), (2) developing disease-modifying strategies targeting nAChR-ligand interactions beyond symptomatic relief, and (3) integrating multi-omics approaches to identify nAChR-associated biomarkers predictive of therapeutic response

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