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Certainly, there is now strong evidence not only for a causal effect on gout but also for associations with metabolic syndrome and related cardiometabolic disorders 2

2017;27(21):R1147-R1151

Elevated levels of LPS have been shown to affect pituitary TSH stimulation, T4 production, and TBG production

Importantly, -KG-deficient cells accumulate disulfide stress and exhibit disulfidptosis features under glucose starvation, which can be largely alleviated by AMPK restoration