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doi: 10.4049/jimmunol.1200501 21 AroraTPadakiRLiuLHamburgerAEEllisonARStevensSRet al

Contemp Oncol (Pozn) (2013) 17(1):15

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The N-terminal acetylation confers enhanced proteolytic stability and improved bioavailability compared to unmodified sequences

Macrodoses of vitamin B12 are absorbed even in the absence of intrinsic factor and hydrochloric acid, as they are not dependent on these, making them a valid strategy for maintenance or recovery in processes or states where this protective protein is not being secreted, such as in gastrectomies, achlorhydria, etc