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discovered that the knockdown of microsomal glutathione S-transferase 1 (MGST1) significantly reduced the protein levels of HO-1 and DNMT1/3 A, leading to decreased DNA methylation in the promoter region of arachidonic acid 15-lipoxygenase (ALOX15)

CXCL4 is one of the most consequential chemokines in the CXC subfamily, and there is evidence that the heterodimer CXCL4-CCL5 has appertained to the process of brain injury, and the addition of inhibitors can significantly enhance neurological function in mice (Vogel et al., 2014

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Hence, the development of an efficient drug delivery system has the potential to facilitate a continuous and regulated release of therapeutic substances, thereby fostering recovery from the secondary damage to the brain following TBI (Mohammed et al., 2023)