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10.21037/jtd.2019.10.43 50

Pinch a fold of skin between thumb and forefinger

Further UQ biosynthesis requires subsequent hydroxylation of C1, C5, and C6 positions of the aromatic ring in PPHB structure catalyzed by flavin-dependent monooxygenases (Coq6 and CoqF) and S-adenosyl-l-methionine-dependent methyltransferases (Coq3 and Coq5) [46]